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Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families
International journal of cancer, 2008-03, Vol.122 (6), p.1422-1425
Romero‐Giménez, Jordi
Dopeso, Higinio
Blanco, Ignacio
Guerra‐Moreno, Angel
Gonzalez, Sara
Vogt, Stefanie
Aretz, Stefan
Schwartz, Simo
Capella, Gabriel
Arango, Diego
2008
Details
Autor(en) / Beteiligte
Romero‐Giménez, Jordi
Dopeso, Higinio
Blanco, Ignacio
Guerra‐Moreno, Angel
Gonzalez, Sara
Vogt, Stefanie
Aretz, Stefan
Schwartz, Simo
Capella, Gabriel
Arango, Diego
Titel
Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families
Ist Teil von
International journal of cancer, 2008-03, Vol.122 (6), p.1422-1425
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome predisposing to colorectal cancer and affects 1 in 5–10,000 births. Inheritance of a mutant allele of the adenomatous polyposis coli (APC) gene is the cause of ∼80% of FAP and 20–30% of an attenuated form of FAP (AFAP), whereas mutations in MUTYH account for a small proportion of the remaining cases. However, the genetic cause of FAP/AFAP in a significant number of families is not known, and cancer risk for individual members of these families cannot be assessed. There is, therefore, an acute need to identify the underlying genetic cause responsible for FAP/AFAP in APC/MUTYH mutation negative families. Hypermethylation of CpG islands in the promoter of tumor suppressor genes can result in gene silencing, has been shown to be functionally equivalent to genetic mutations and can be inherited. Moreover, APC promoter hypermethylation is observed in ∼20% of sporadic colorectal tumors and correlates with the loss of gene expression. In our study, we used bisulfite treatment and direct sequencing of 2 regulatory regions of APC containing a total of 25 CpG dinucleotides, to investigate the possible role of germline hypermethylation of the APC promoter in FAP and AFAP families that were negative for APC and MUTYH mutations. Analysis of 21 FAP and 39 AFAP families did not identify signs of abnormal promoter methylation, indicating that this form of epigenetic silencing is not a common cause of FAP/AFAP. These results substantially contribute to clarify the potential role of germline epimutations as a cause of inherited predisposition to cancer. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.23247
Titel-ID: cdi_proquest_miscellaneous_70241456
Format
–
Schlagworte
Adenomatous Polyposis Coli - genetics
,
AFAP
,
APC
,
Base Sequence
,
Biological and medical sciences
,
colorectal cancer
,
CpG Islands
,
DNA Glycosylases - genetics
,
DNA Methylation
,
DNA Primers
,
FAP
,
Gastroenterology. Liver. Pancreas. Abdomen
,
Genes, APC
,
Germ-Line Mutation
,
Humans
,
Medical sciences
,
promoter methylation
,
Promoter Regions, Genetic
,
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
,
Tumors
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