Details

Autor(en) / Beteiligte

• Biasin, Mara
• Piacentini, Luca
• Lo Caputo, Sergio
• Kanari, Yasuyoshi
• Magri, Guiliana
• Trabattoni, Daria
• Naddeo, Valentina
• Lopalco, Lucia
• Clivio, Alberto
• Cesana, Eugenio
• Fasano, Francesca
• Bergamaschi, Cristina
• Mazzotta, Francesco
• Miyazawa, Masaaki
• Clerici, Mario

Titel

Apolipoprotein B mRNA—Editing Enzyme, Catalytic Polypeptide—Like 3G: A Possible Role in the Resistance to HIV of HIV-Exposed Seronegative Individuals

Ist Teil von

• The Journal of infectious diseases, 2007-04, Vol.195 (7), p.960-964

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Apolipoprotein B mRNA—editing enzyme, catalytic polypeptide—like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIVexposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)—mainly CD14+ cells—and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1Ba-L R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.