Details

Autor(en) / Beteiligte

• Kato, Masashi
• Takeda, Kozue
• Kawamoto, Yoshiyuki
• Hossain, Khaled
• Ohgami, Nobutaka
• Yanagishita, Takeshi
• Ohshima, Yuichiro
• Kato, Yoko
• Ohgami, Kyoko
• Yamamori, Tatsuya
• Tateyama, Keisuke
• Yamanoshita, Osamu

Titel

Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation

Ist Teil von

• Nippon eiseigaku zasshi, 2007-01, Vol.62 (1), p.3-8

Ort / Verlag

Japan

Erscheinungsjahr

2007

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.