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Sodium/calcium exchanger expression in the mouse and rat olfactory systems
Journal of comparative neurology (1911), 2007-04, Vol.501 (6), p.944-958
Pyrski, Martina
Koo, Jae Hyung
Polumuri, Swamy K.
Ruknudin, Abdul M.
Margolis, Joyce W.
Schulze, Dan H.
Margolis, Frank L.
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Pyrski, Martina
Koo, Jae Hyung
Polumuri, Swamy K.
Ruknudin, Abdul M.
Margolis, Joyce W.
Schulze, Dan H.
Margolis, Frank L.
Titel
Sodium/calcium exchanger expression in the mouse and rat olfactory systems
Ist Teil von
Journal of comparative neurology (1911), 2007-04, Vol.501 (6), p.944-958
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Sodium/calcium (Na+/Ca2+) exchangers are membrane transport systems that regulate Ca2+‐homeostasis in many eukaryotic cells. In olfactory and vomeronasal sensory neurons ligand‐induced olfactory signal transduction is associated with influx and elevation of intracellular Ca2+, [Ca2+]i. While much effort has been devoted to the characterization of Ca2+‐related excitation and adaptation events of olfactory chemosensory neurons (OSNs), much less is known about mechanisms that return [Ca2+]i to the resting state. To identify proteins participating in the poststimulus Ca2+‐clearance of mouse OSNs, we analyzed the expression of three potassium (K+)‐independent (NCX1, 2, 3) and three K+‐dependent (NCKX1, 2, 3) Na+/Ca2+ exchangers. In situ hybridization showed that mRNAs of all six Na+/Ca2+ exchangers coexist in neurons of the olfactory and vomeronasal systems, and that some are already detectable in the embryo. Of these, NCX1 and NCKX1 represent the most and least abundant mRNAs, respectively. Moreover, immunohistochemistry revealed that the NCX1, 2, and 3 proteins are expressed in nearly all neurons of the olfactory epithelium, the vomeronasal organ, the septal organ of Masera, and the Grueneberg ganglion. These three exchanger proteins display different expression profiles in dendrites, knobs, and plasma membranes of OSNs and in sustentacular cells. Furthermore, we show that NCX1 mRNA in rat olfactory mucosa is expressed as 8 alternative splice variants. This is the first comprehensive analysis of Na+/Ca2+ exchanger expression in the mammalian olfactory system. Our results suggest that Ca2+‐extrusion by OSNs utilizes multiple different Na+/Ca2+ exchangers and that different subtypes are targeted to different subcellular compartments. J. Comp. Neurol. 501:944–958, 2007. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/cne.21290
Titel-ID: cdi_proquest_miscellaneous_70221358
Format
–
Schlagworte
Age Factors
,
Animals
,
Ca2+-clearance
,
Calcium - metabolism
,
Female
,
Male
,
Mice
,
NCX
,
Neurons, Afferent - cytology
,
Neurons, Afferent - metabolism
,
olfaction
,
Olfactory Mucosa - cytology
,
Olfactory Mucosa - metabolism
,
Olfactory Pathways - cytology
,
Olfactory Pathways - metabolism
,
Protein Isoforms - metabolism
,
Rats
,
Rats, Sprague-Dawley
,
RNA, Messenger - analysis
,
signal transduction
,
Smell - physiology
,
Sodium-Calcium Exchanger - classification
,
Sodium-Calcium Exchanger - genetics
,
Sodium-Calcium Exchanger - metabolism
,
Vomeronasal Organ - cytology
,
Vomeronasal Organ - metabolism
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