UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 24 von 305
Datensatz exportieren als...
BibTeX
Up‐regulation of NADPH oxidase components and increased production of interferon‐gamma by leukocytes from sickle cell disease patients
American journal of hematology, 2008-01, Vol.83 (1), p.41-45
Marçal, Lívia E.
Dias‐da‐Motta, Péricles M.
Rehder, Jussara
Mamoni, Ronei L.
Blotta, Maria Heloísa S.L.
Whitney, Constance B.
Newburger, Peter E.
Costa, Fernando F.
Saad, Sara T.O.
Condino‐Neto, Antonio
2008
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Marçal, Lívia E.
Dias‐da‐Motta, Péricles M.
Rehder, Jussara
Mamoni, Ronei L.
Blotta, Maria Heloísa S.L.
Whitney, Constance B.
Newburger, Peter E.
Costa, Fernando F.
Saad, Sara T.O.
Condino‐Neto, Antonio
Titel
Up‐regulation of NADPH oxidase components and increased production of interferon‐gamma by leukocytes from sickle cell disease patients
Ist Teil von
American journal of hematology, 2008-01, Vol.83 (1), p.41-45
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
We have previously demonstrated that mononuclear leukocytes from patients with sickle cell disease (SCD) release higher amounts of superoxide compared with normal controls. The aim of this study was to further study the NADPH oxidase system in these patients by investigating gene expression of NADPH oxidase components, phosphorylation of p47phox component, and the release of cytokines related to NADPH oxidase activation in mononuclear leukocytes from patients with SCD. gp91phox gene expression was significantly higher in monocytes from SCD patients compared with normal controls (P = 0.036). Monocytes from SCD patients showed higher levels of p47phox phosphorylation compared with normal controls. INF‐γ release by lymphocytes from SCD patients was significantly higher compared with normal controls, after 48 h culture with phytohemagglutinin (P = 0.02). The release of TNF‐α by monocytes from SCD patients and normal controls was similar after 24 and 48 h culture with lipopolysaccharide (P > 0.05). We conclude that monocytes from SCD patients show higher levels of gp91phox gene expression and p47phox phosphorylation, along with increased IFN‐γ release by SCD lymphocytes. These findings help to explain our previous observation showing the increased respiratory burst activity of mononuclear leukocytes from SCD patients and may contribute to inflammation and tissue damage in these patients. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0361-8609
eISSN: 1096-8652
DOI: 10.1002/ajh.20991
Titel-ID: cdi_proquest_miscellaneous_70217753
Format
–
Schlagworte
Adolescent
,
Adult
,
Anemia, Sickle Cell - metabolism
,
Anemias. Hemoglobinopathies
,
Biological and medical sciences
,
Diseases of red blood cells
,
Female
,
Gene Expression Regulation, Enzymologic
,
Hematologic and hematopoietic diseases
,
Humans
,
Interferon-gamma - biosynthesis
,
Isoenzymes - genetics
,
Isoenzymes - metabolism
,
Leukocytes - metabolism
,
Male
,
Medical sciences
,
Middle Aged
,
NADPH Oxidases - genetics
,
NADPH Oxidases - metabolism
,
Phosphorylation
,
RNA, Messenger - genetics
,
Transcription, Genetic - genetics
,
Tumor Necrosis Factor-alpha - biosynthesis
,
Up-Regulation
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX