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Details

Autor(en) / Beteiligte
Titel
Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: A randomized clinical trial
Ist Teil von
  • Journal of ethnopharmacology, 2007-03, Vol.110 (2), p.305-310
Ort / Verlag
Shannon: Elsevier Ireland Ltd
Erscheinungsjahr
2007
Quelle
MEDLINE
Beschreibungen/Notizen
  • To assess the efficacy of two different doses of a Psidii guajavae folium extract in the management of primary dysmenorrhea. A double-blinded randomized clinical trial was conducted in 197 women with primary dysmenorrhea. Four intervention groups were defined: two extract doses (3 and 6 mg/day); ibuprofen (1200 mg/day); placebo (3 mg/day). Participants were followed-up individually for 4 months. The main outcome variable was abdominal pain intensity measured according to a visual analogue scale (VAS). The average age of participants was 19 years; menarche occurred around age 12 years. Participants had menstrual cycles of 28 or 29 days, with menstruation lasting 5 days and mean of pain intensity of 8.2 on the VAS. During each successive treatment cycle, participants experienced a lower pain intensity score. Multiple regression analysis, after adjusting each cycle for baseline pain, treatment compliance and other variables, showed that the group receiving 6 mg/day extract had significantly reduced pain intensity ( p < 0.001). This effect was maintained in cycles 2 and 3, although the reduction in the mean of pain intensity was lower. The group receiving the 3 mg/day extract did not show a consistent effect throughout the three cycles. At a dose of 6 mg/day, the standardized phyto-drug ( Psidii guajavae folium extract) reduced menstrual pain significantly compared with conventional treatment and placebo.

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