UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 13 von 22
Datensatz exportieren als...
BibTeX
Clinical and Technical Factors Affecting pH and Other Biomarkers in Exhaled Breath Condensate
Pediatric pulmonology, 2006-01, Vol.41 (1), p.87-94
Leung, Ting F.
Li, Chung Y.
Yung, Edmund
Liu, Eric K.H.
Lam, Christopher W.K.
Wong, Gary W.K.
2006
Details
Autor(en) / Beteiligte
Leung, Ting F.
Li, Chung Y.
Yung, Edmund
Liu, Eric K.H.
Lam, Christopher W.K.
Wong, Gary W.K.
Titel
Clinical and Technical Factors Affecting pH and Other Biomarkers in Exhaled Breath Condensate
Ist Teil von
Pediatric pulmonology, 2006-01, Vol.41 (1), p.87-94
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Exhaled breath condensate (EBC) pH appears to be a robust measure of asthma. However, the association between EBC pH and clinical factors and airway inflammatory markers remains unclear. The objectives of this study were to investigate the factors determining EBC pH in asthmatic children, and the reproducibility and effects of collection devices on EBC pH in nine healthy, nonsmoking adults. EBC was collected once from asthmatic children using EcoScreen, and from adults over 3 consecutive days using both RTubes and EcoScreen. EBC pH was measured immediately in non‐deaerated samples by microelectrode pH meter. Concentrations of 8‐isoprostane, cysteinyl leukotrienes (cys‐LT), and leukotriene B4 (LTB4) were measured using enzyme immunoassay. Exhaled nitric oxide concentration (FeNO) was measured by chemiluminescence. Fifty‐eight asthmatics (16 intermittent, 12 mild persistent, and 30 moderate‐to‐severe persistent) were recruited. EBC pH was lower among patients with moderate‐to‐severe persistent than intermittent asthma (P = 0.046). This marker correlated inversely with disease severity score (ρ = −0.276, P = 0.036), but not FeNO or other EBC biomarkers. Bland‐Altman analyses found pH but not other EBC biomarkers to be reproducible, which were confirmed by its low coefficient of variation (2.7%; range, 0.4–5.2%). There was poor correlation between pH in EBC collected by RTube and EcoScreen (ρ = 0.059, P = 0.784). Factor analysis selected four factors that explained 67.5% of the total variance, and EBC pH clustered with both cys‐LT and LTB4. In conclusion, our results suggest that pH in non‐deaerated EBC is influenced by asthma severity in children. EBC pH measurement is reproducible, but is dependent on the collection devices used. Pediatr Pulmonol. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.20296
Titel-ID: cdi_proquest_miscellaneous_70201117
Format
–
Schlagworte
8-isoprostane
,
acidity
,
Adolescent
,
Adult
,
asthma
,
Asthma - diagnosis
,
Asthma - metabolism
,
Biological and medical sciences
,
Biomarkers - analysis
,
Breath Tests - instrumentation
,
Child
,
children
,
Chronic obstructive pulmonary disease, asthma
,
Cysteine - analysis
,
Dinoprost - analogs & derivatives
,
Dinoprost - analysis
,
exhaled breath condensate
,
Factor Analysis, Statistical
,
Female
,
Forced Expiratory Volume
,
Humans
,
Hydrogen-Ion Concentration
,
Immunoenzyme Techniques
,
leukotriene
,
Leukotriene B4 - analysis
,
Leukotrienes - analysis
,
Luminescent Measurements
,
Male
,
Medical sciences
,
Nitric Oxide - analysis
,
Pneumology
,
Reproducibility of Results
,
Severity of Illness Index
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX