Details

Autor(en) / Beteiligte

• Onodera, Taishi
• Poe, Jonathan C
• Tedder, Thomas F
• Tsubata, Takeshi

Titel

CD22 Regulates Time Course of Both B Cell Division and Antibody Response

Ist Teil von

• The Journal of immunology (1950), 2008-01, Vol.180 (2), p.907-913

Ort / Verlag

United States: Am Assoc Immnol

Erscheinungsjahr

2008

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."