Zhong hua yi xue za zhi, 2007-12, Vol.87 (45), p.3178-3182
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Clinical study and prenatal diagnosis of fetus with shortened long bones
- Ist Teil von
- Zhong hua yi xue za zhi, 2007-12, Vol.87 (45), p.3178-3182
- Ort / Verlag
- China
- Erscheinungsjahr
- 2007
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- To investigate the manifestations and prenatal diagnosis of the fetus with shortened long bones. Ultrasonography was conducted on 57 fetuses with shortened long bones and 62 normal fetuses. Percutaneous umbilical blood sampling was performed on the 57 cases to undergo examination of karyotype and mutation in exon 10 of fibroblast growth factor receptor (FGFR)3 gene. Fetal radiography and autopsy were performed in 30 abnormal induced fetuses. Among the 57 fetuses of the shortened long bones group 21 (37%) were diagnosed as with specific skeletal dysplasia postnatally, abnormal chromosome were found in 8 (14%), 4 (7%) were with fetal growth restriction, and 24 (42%) were with unknown etiology. Prenatal ultrasonography showed that in the fetuses with skeletal dysplasia the value of standard deviation score (SD) for femur length and/or humerus length fell to -4 SD of the corresponding pregnancy week, and increase of biparietal diameter was often found; in the fetuses with abnormal chromosome and fetal growth rest
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0376-2491Titel-ID: cdi_proquest_miscellaneous_70132948
- Format
- –
- Schlagworte
- Adult, Bone Diseases, Developmental - diagnostic imaging, Bone Diseases, Developmental - genetics, Exons - genetics, Female, Femur - abnormalities, Femur - diagnostic imaging, Fetal Diseases - diagnostic imaging, Fetal Diseases - genetics, Humans, Pregnancy, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Receptor, Fibroblast Growth Factor, Type 3 - genetics, Ultrasonography, Prenatal