Details

Autor(en) / Beteiligte

• Westerterp, Marinke
• Sloof, Gerrit W.
• Hoekstra, Otto S.
• ten Kate, Fiebo J. W.
• Meijer, Gerrit A.
• Reitsma, Johannes B.
• Boellaard, Ronald
• van Lanschot, J. Jan B.
• Molthoff, Carla F. M.

Titel

18FDG uptake in oesophageal adenocarcinoma: linking biology and outcome

Ist Teil von

• Journal of cancer research and clinical oncology, 2008-02, Vol.134 (2), p.227-236

Ort / Verlag

Berlin/Heidelberg: Springer-Verlag

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose Variable uptake of 18 FDG has been noticed in positron emission tomography (PET) studies of patients with oesophageal adenocarcinoma. The aim of the present study was to investigate biological parameters involved in 18 FDG uptake in oesophageal adenocarcinoma for selection of patients with increased 18 FDG uptake and prediction of prognostic value of 18 FDG PET. Patients and methods Preoperative PET scans were performed in 26 patients with histologically proven oesophageal adenocarcinoma. 18 FDG uptake was semiquantitatively measured by SUV BSAg. Tumour sections were stained by immunohistochemistry for angiogenic markers (VEGF, CD31), glucose transporter-1 (Glut-1), hexokinase (HK) isoforms, for proliferation marker (Ki67), for macrophage marker (CD68) and for apoptosis marker (cleaved caspase-3). Cell densities, differentiation grade, degree of necrosis and mucus, T-stage and tumour size were assessed. In addition follow-up was analysed. Results No association was found between 18 FDG uptake and angiogenic markers. In contrast, a significant correlation was found between 18 FDG uptake and Glut-1 expression. No correlations were found between 18 FDG uptake and HK isoforms, Ki67 or cleaved caspase-3. Also, no correlations were found between 18 FDG uptake and cell density, differentiation grade, CD68, mucus and necrosis. However, there was a significant correlation between 18 FDG uptake and tumour size and between 18 FDG uptake and tumour recurrence. Conclusions Glut-1 expression and tumour size seem parameters associated with 18 FDG uptake in patients with biopsy proven oesophageal adenocarcinoma, and may be used to select oesophageal cancer patients in whom 18 FDG-PET is of diagnostic value and may predict disease outcome.