Details

Autor(en) / Beteiligte

• Shields, Anthony F
• Grierson, John R
• Dohmen, Bernhard M
• Machulla, H.-Juergen
• Stayanoff, Joseph C
• Lawhorn-Crews, Jawana M
• Obradovich, Joyce E
• Muzik, Otto
• Mangner, Thomas J

Titel

Imaging proliferation in vivo with [F-18]FLT and positron emission tomography

Ist Teil von

• Nature medicine, 1998-11, Vol.4 (11), p.1334-1336

Ort / Verlag

United States

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.