Details

Autor(en) / Beteiligte

• Hagan, Jim J.
• Leslie, Ron A.
• Patel, Sara
• Evans, Martyn L.
• Wattam, Trevor A.
• Holmes, Steve
• Benham, Christopher D.
• Taylor, Stephen G.
• Routledge, Carol
• Hemmati, Panida
• Munton, Richard P.
• Ashmeade, Tracey E.
• Shah, Ajit S.
• Hatcher, Jonathan P.
• Hatcher, Paula D.
• Declan N. C. Jones
• Smith, Martin I.
• Piper, David C.
• Hunter, A. Jackie
• Porter, Rod A.
• Upton, Neil

Titel

Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (19), p.10911-10916

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.