Regulatory peptides, 1998-09, Vol.75, p.89-92
1998
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- Autor(en) / Beteiligte
- Titel
- Immunolocalization of neuropeptide Y in human pituitary tumours
- Ist Teil von
- Regulatory peptides, 1998-09, Vol.75, p.89-92
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 1998
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Neuropeptide Y (NPY) gene is expressed in human pituitary gland where its function is partially elucidated. NPY could act as a neuroendocrine modulator within this gland. This study was undertaken to assess whether NPY expression is correlated to various pathological situations. Using a highly specific anti-NPY monoclonal antibody, immunohistochemistry analysis was performed in surgically removed pituitary glands. The study included biopsies from 112 human pituitary adenomas, 12 hyperplastic glands and normal anterior pituitary tissues in 34 cases. NPY is immunodetected in 33% of all adenomas, 25% hyperplastic glands and 12% of non-tumoral pituitary gland. NPY expression was significantly higher in adenomas compared to the normal gland. However, no correlation was observed between NPY content and the type of hormonal secretion, sex, age and the status of tumour proliferating potential.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-0115eISSN: 1873-1686DOI: 10.1016/S0167-0115(98)00056-1Titel-ID: cdi_proquest_miscellaneous_70023594
- Format
- –
- Schlagworte
- Adenoma - metabolism, Adenoma - pathology, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Child, Child, Preschool, Female, Gonadotropins, Pituitary - metabolism, Human Growth Hormone - metabolism, Human tumours, Humans, Hyperplasia, Immunohistochemistry, Infant, Male, Middle Aged, Neuropeptide Y, Neuropeptide Y - immunology, Neuropeptide Y - metabolism, Pituitary gland, Pituitary Gland, Anterior - metabolism, Pituitary Gland, Anterior - pathology, Pituitary Neoplasms - metabolism, Pituitary Neoplasms - pathology