Details

Autor(en) / Beteiligte

• Rakshi, J. S.
• Uema, T.
• Ito, K.
• Bailey, D. L.
• Morrish, P. K.
• Ashburner, J.
• Dagher, A.
• Jenkins, I. H.
• Friston, K. J.
• Brooks, D. J.

Titel

Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [18F]dopa-PET study

Ist Teil von

• Brain (London, England : 1878), 1999-09, Vol.122 (9), p.1637-1650

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

1999

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We have studied focal changes in dopaminergic function throughout the brain volume in early and advanced Parkinson's disease by applying statistical parametric mapping (SPM) to 3D [18F]dopa-PET. Data from seven early hemi-Parkinson's disease and seven advanced bilateral Parkinson's disease patients were compared with that from 12 normal controls. Parametric images of [18F]dopa influx rate constant (Kio) were generated for each subject from dynamic 3D [18F]dopa datasets and transformed into standard stereotactic space. Significant changes in mean voxel [18F]dopa Kio values between the normal control group and each Parkinson's disease group were localized with SPM. Conventional region of interest analysis was also applied to comparable regions on the untransformed image datasets. In early left hemi-Parkinson's disease, significant extrastriatal increases in [18F]dopa Kio were observed in the left anterior cingulate gyrus and the dorsal midbrain region (P < 0.05, corrected) along with decreases in striatal [18F]dopa Kio. In advanced Parkinson's disease, significant extrastriatal decreases in [18F]dopa Kio were observed in the ventral and dorsal midbrain regions (P < 0.05, corrected). No significant changes in [18F]dopa Kio were observed in the anterior cingulate region. In a direct comparison between the early and late Parkinson's disease groups, we observed relative [18F]dopa Kio reductions in ventral and dorsal midbrain, and dorsal pontine regions along with striatal [18F]dopa Kio reductions. Similiar results were found with a region of interest approach, on non-transformed data, except for the focal midbrain [18F]dopa Kio increase seen in early Parkinson's disease. In conclusion, using SPM with [18F]dopa-PET, we have objectively localized changes in extrastriatal, pre-synaptic dopaminergic function in Parkinson's disease. The significance of the increased dopaminergic activity of anterior cingulate in early Parkinson's disease remains unclear, but may be compensatory. The [18F]dopa signal in dorsal midbrain and pontine regions suggests that [18F]dopa is taken up by serotonergic and noradrenergic neurons which also degenerate in advanced Parkinson's disease. This suggests, therefore, that Parkinson's disease is a monoaminergic neurodegenerative disorder.