Cell, 1998-10, Vol.95 (2), p.189-198
1998
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Details
- Autor(en) / Beteiligte
- Titel
- Lipid A Acylation and Bacterial Resistance against Vertebrate Antimicrobial Peptides
- Ist Teil von
- Cell, 1998-10, Vol.95 (2), p.189-198
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 1998
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The Salmonellae PhoP-PhoQ virulence regulators induce resistance to host cationic antimicrobial peptides (CAMP) after infection of vertebrate tissues, and Mg 2+ or Ca 2+ limitation. The PhoP-PhoQ activated gene, pagP, was identified as important to inducible CAMP resistance and increased acylation of lipid A, the major component of the outer leaflet of the outer membrane. pagP mutants demonstrated increased outer membrane permeability in response to CAMP, supporting the hypothesis that increased lipid A acylation is a CAMP resistance mechanism. Similarly, in response to Mg 2+ limited growth, other enteric Gram-negative bacteria demonstrated increased lipid A acylation. Compounds that inhibit the ability to increase lipid A acylation may have utility as new antimicrobial agents.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0092-8674eISSN: 1097-4172DOI: 10.1016/S0092-8674(00)81750-XTitel-ID: cdi_proquest_miscellaneous_70004050
- Format
- –
- Schlagworte
- Acylation, Anti-Bacterial Agents - metabolism, Bacterial Proteins - genetics, Cations - metabolism, Cell Division - drug effects, Cell Membrane - metabolism, Chromosomes, Bacterial, Culture Media, Drug Resistance, Microbial, Escherichia coli - chemistry, Escherichia coli - growth & development, Lipid A - metabolism, Magnesium - pharmacology, Molecular Sequence Data, Palmitates - metabolism, Peptides, Salmonella, Salmonella typhimurium - chemistry, Salmonella typhimurium - metabolism, Salmonella typhimurium - pathogenicity, Transcription Factors - genetics, Virulence, Yersinia enterocolitica - chemistry, Yersinia enterocolitica - growth & development