Zhōngguó yàolĭ xuébào, 1999-04, Vol.20 (4), p.353-357
1999
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Details
- Autor(en) / Beteiligte
- Titel
- IL-10 and trichosanthin inhibited surface molecule expression of antigen processing cells and T-cell proliferation
- Ist Teil von
- Zhōngguó yàolĭ xuébào, 1999-04, Vol.20 (4), p.353-357
- Ort / Verlag
- China
- Erscheinungsjahr
- 1999
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To study immunoinhibitory effects and preliminary mechanism of IL-10 and trichosanthin. Surface molecule expression on antigen processing cells (APC) was stained with fluorescence and analyzed by FACScan. B7-1 mRNA expression was detected with nested RT-PCR. IL-10 2 mg.L-1 and trichosanthin 10 mg.L-1 inhibited B7-1 molecule expression. By contrast, they had not the same effects on ICAM-1. IL-10 and trichosanthin down-regulated LFA-1 expression, but had no regulatory effect on CD40. IL-10 and trichosanthin dramatically inhibited T-cell proliferation and IL-2 production. B7-1 mRNA expression was undetectable in APC treated with IL-10 and trichosanthin. IL-10 and trichosanthin inhibit surface molecule expression on APC. They exert multiple immunoinhibitory effects.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0253-9756Titel-ID: cdi_proquest_miscellaneous_69967533
- Format
- –
- Schlagworte
- AIDS/HIV, Antigen-Presenting Cells - immunology, B7-1 Antigen - biosynthesis, B7-1 Antigen - genetics, Cell Division - drug effects, Humans, Interleukin-10 - pharmacology, Lymphocyte Function-Associated Antigen-1 - biosynthesis, Lymphocyte Function-Associated Antigen-1 - genetics, RNA, Messenger - genetics, T-Lymphocytes - drug effects, Trichosanthin - pharmacology