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BibTeX
Immunostaining for vasostatin I distinguishes between ileal and lung carcinoids
The Journal of pathology, 1999-02, Vol.187 (3), p.321-325
Cunningham, Rodat T.
Pogue, Kathy M.
Curry, William J.
Johnston, Colin F.
Sloan, James M.
Buchanan, Keith D.
1999
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Cunningham, Rodat T.
Pogue, Kathy M.
Curry, William J.
Johnston, Colin F.
Sloan, James M.
Buchanan, Keith D.
Titel
Immunostaining for vasostatin I distinguishes between ileal and lung carcinoids
Ist Teil von
The Journal of pathology, 1999-02, Vol.187 (3), p.321-325
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
1999
Quelle
MEDLINE
Beschreibungen/Notizen
Although chromogranin A (CgA) is a recognized marker of neuroendocrine tumours, little is known about the distribution of the CgA‐derived peptides, vasostatin (VST) I or II, in these tumours. Rabbit polyclonal antiserum was raised to a fragment of VST I and used to immunostain sections (5μm) of wax‐embedded tumour tissue. Immunoreactivity (IR) was detected using swine anti‐rabbit fluorescein secondary antibody and sections were viewed by fluorescence microscopy. Of 24 tumours from patients with lung carcinoids, one was weakly positive, while 23 of 26 ileal carcinoid tumours were immunoreactive. Metastatic deposits from patients with ileal carcinoids also tended to be immunoreactive (9/10). The difference in IR between lung and ileal carcinoid primary tumours did not appear to be related to the metastatic potential, since appendiceal tumours, which seldom metastasize, also tended to be immunoreactive (4/6) for VST I. The strongest IR was recorded in two patients with flushing as a result of ileal carcinoids; five other ‘flushers’ with ileal carcinoids were also immunopositive for VST I‐like IR. By contrast, patients with flushing as a result of lung carcinoids were immunonegative for VST. In conclusion, VST I‐like IR may assist in the identification of a secondary deposit from an unknown primary site. Copyright © 1999 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/(SICI)1096-9896(199902)187:3<321::AID-PATH258>3.0.CO;2-9
Titel-ID: cdi_proquest_miscellaneous_69952408
Format
–
Schlagworte
Biological and medical sciences
,
Biomarkers, Tumor - analysis
,
Carcinoid Tumor - diagnosis
,
Carcinoid Tumor - secondary
,
carcinoid tumours
,
Chromogranin A
,
Chromogranins - analysis
,
diagnosis
,
Diagnosis, Differential
,
Fluorescent Antibody Technique
,
Flushing - metabolism
,
Humans
,
Ileal Neoplasms - diagnosis
,
Investigative techniques, diagnostic techniques (general aspects)
,
Lung Neoplasms - diagnosis
,
Medical sciences
,
Miscellaneous. Technology
,
neuroendocrine tumours
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
Peptide Fragments - analysis
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