Details

Autor(en) / Beteiligte

• Bovin, Lone Frier
• Fredman, Pam
• Månsson, Jan-Eric
• Buschard, Karsten
• Bendtzen, Klaus

Titel

In vitro production of cytokines is influenced by sulfatide and its precursor galactosylceramide

Ist Teil von

• FEBS letters, 1999-07, Vol.455 (3), p.339-343

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

1999

Quelle

ScienceDirect

Beschreibungen/Notizen

• Effects of sulfatide and its precursor galactosylceramide (gal-cer) on the kinetics of production of cytokines were studied. In human mononuclear leucocytes, gal-cer but not sulfatide induced significantly increased amounts of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF) mRNA. In phytohemagglutinin-stimulated cultures, gal-cer increased the levels of IL-1β and IL-6 mRNA and secreted IL-1β and IL-6, while sulfatide decreased the amounts of IL-6 mRNA and secreted IL-6. Gal-cer also increased TNF secretion. In lipopolysaccharide-stimulated cells, sulfatide but not gal-cer decreased the secretion of IL-1β and IL-10, a potent suppressor of production of many cytokines. Thus, sulfatide and gal-cer affect cytokine production differently, most likely at the level of gene expression. This may have implications in diseases where inflammatory cytokines play a pathogenic role.