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Acoustic startle reflex in schizophrenia patients and their first-degree relatives: Evidence of normal emotional modulation
Ist Teil von
Psychophysiology, 1999-07, Vol.36 (4), p.469-475
Ort / Verlag
Oxford, UK: Cambridge University Press
Erscheinungsjahr
1999
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
We investigated emotional disturbances in 36 schizophrenia
patients, 48 of their first-degree relatives, and 56 controls
to determine if abnormal affective startle modulation could
be associated with genetic risk for schizophrenia. Both
patients and relatives had a pattern of startle modulation
indistinguishable from controls, with potentiated startle
amplitude while viewing negative valence slides and attenuation
while viewing positive slides. Patients with flat affect
did not differ from those without in startle modulation
or slide ratings. The patients and their relatives had
lower pleasantness ratings of positive slides and the patients
had higher pleasantness ratings of the negative slides
than controls. The startle paradigm may not be useful
for identifying individuals with a genetic liability for
schizophrenia. The results suggest that low-level defensive
and appetitive behaviors are unaffected in schizophrenia.