Details

Autor(en) / Beteiligte

• Ishihara, Akihiko
• Fujino, Hidemi
• Nagatomo, Fumiko
• Takeda, Isao
• Ohira, Yoshinobu

Titel

Gene Expression Levels of Heat Shock Proteins in the Soleus and Plantaris Muscles of Rats after Hindlimb Suspension or Spaceflight

Ist Teil von

• The Journal of Physiological Sciences, 2008, Vol.58(6), pp.413-417

Ort / Verlag

Japan: PHYSIOLOGICAL SOCIETY OF JAPAN

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Gene expression levels of heat shock proteins (HSPs) in the slow-twitch soleus and fast-twitch plantaris muscles of rats were determined after hindlimb suspension or spaceflight. Male rats were hindlimb-suspended for 14 d or exposed to microgravity for 9 d. The mRNA expression levels of HSP27, HSP70, and HSP84 in the hindlimb-suspended and microgravity-exposed groups were compared with those in the controls. The mRNA expression levels of the 3 HSPs in the soleus muscle under normal conditions were higher compared with those in the plantaris muscle. The mRNA expression levels of the 3 HSPs in the soleus muscle were inhibited by hindlimb suspension and spaceflight. The mRNA expression levels of the 3 HSPs in the plantaris muscle did not change after hindlimb suspension. It is suggested that the mRNA expression levels of the 3 HSPs are regulated by the mechanical and neural activity levels, and therefore the decreased mRNA expression levels of HSPs in the slow-twitch muscle following hindlimb suspension and spaceflight are related to a reduction in the mechanical and neural activity levels.