BioFactors (Oxford), 1999, Vol.9 (2-4), p.163-170
1999
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- Autor(en) / Beteiligte
- Titel
- Protective role of ubiquinone in vitamin E and selenium-deficient plasma membranes
- Ist Teil von
- BioFactors (Oxford), 1999, Vol.9 (2-4), p.163-170
- Ort / Verlag
- Amsterdam: IOS Press
- Erscheinungsjahr
- 1999
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- We have studied the effects of dietary depletion of vitamin E and selenium on endogenous ubiquinone‐dependent antioxidant system. Deficiency induced an increase in both coenzyme Q9 and Q10 in liver tissue, reaching a maximum between 4 and 7 weeks of deficient diet consumption. Cytochrome b5 reductase polypeptide was also enriched in membranes after 5 weeks of deficient diet consumption. Substantial DT‐diaphorase activity was found in deficient, but not in control plasma membranes. Deficient membranes were very sensitive to lipid peroxidation, although a great protection was observed after incubation with NAD(P)H. Our results show that liver cells can boost endogenous ubiquinone‐dependent protective mechanisms in response to deficiency in vitamin E and selenium.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0951-6433eISSN: 1872-8081DOI: 10.1002/biof.5520090211Titel-ID: cdi_proquest_miscellaneous_69904974
- Format
- –
- Schlagworte
- Animals, Cell Membrane - drug effects, Cell Membrane - metabolism, Coenzymes, Cytochrome Reductases - metabolism, Cytochrome-B Reductase, Dihydrolipoamide Dehydrogenase - metabolism, Electron Transport, Lipid Peroxidation - drug effects, Liver - drug effects, Liver - metabolism, Male, NAD - metabolism, NADP - metabolism, Rats, Rats, Long-Evans, Selenium - deficiency, Selenium - metabolism, Selenium - pharmacology, Time Factors, Ubiquinone - analogs & derivatives, Ubiquinone - metabolism, Vitamin E - metabolism, Vitamin E - pharmacology, Vitamin E Deficiency - metabolism