Nature, 2008-12, Vol.456 (7223), p.745-749
2008
Details
- Autor(en) / Beteiligte
- Titel
- Brain metabolism dictates the polarity of astrocyte control over arterioles
- Ist Teil von
- Nature, 2008-12, Vol.456 (7223), p.745-749
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles. However, the mechanism for how these opposite astrocyte influences provide appropriate changes in vessel tone within an environment that has dynamic metabolic requirements remains unclear. Here we show that the ability of astrocytes to induce vasodilations over vasoconstrictions relies on the metabolic state of the rat brain tissue. When oxygen availability is lowered and astrocyte calcium concentration is elevated, astrocyte glycolysis and lactate release are maximized. External lactate attenuates transporter-mediated uptake from the extracellular space of prostaglandin E(2), leading to accumulation and subsequent vasodilation. In conditions of low oxygen concentration extracellular adenosine also increases, which blocks astrocyte-mediated constriction, facilitating dilation. These data reveal the role of metabolic substrates in regulating brain blood flow and provide a mechanism for differential astrocyte control over cerebrovascular diameter during different states of brain activation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687, 1476-4679DOI: 10.1038/nature07525Titel-ID: cdi_proquest_miscellaneous_69898700
- Format
- –
- Schlagworte
- Adenosine - metabolism, Adenosine - pharmacology, Animals, Arterioles - drug effects, Arterioles - metabolism, Astrocytes, Astrocytes - metabolism, Biological and medical sciences, Biomedical research, Brain, Brain - blood supply, Brain - metabolism, Changes, Dinoprostone - metabolism, Fluorescence, Fundamental and applied biological sciences. Psychology, Glycolysis, Lactic Acid - metabolism, Male, Medical imaging, Metabolism, Nitric oxide, Organic Anion Transporters - metabolism, Oxygen - metabolism, Physiological aspects, Pressure, Prostaglandin-Endoperoxide Synthases - metabolism, Rats, Rats, Sprague-Dawley, Rodents, Vasoconstriction - drug effects, Vasoconstriction - physiology, Vasodilation - drug effects, Vasodilation - physiology, Vasodilator Agents - pharmacology, Vertebrates: nervous system and sense organs