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Atopic dermatitis: Therapeutic concepts evolving from new pathophysiologic insights
Ist Teil von
Journal of allergy and clinical immunology, 2008-12, Vol.122 (6), p.1074-1081
Ort / Verlag
New York, NY: Mosby, Inc
Erscheinungsjahr
2008
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Recent insights into the relevance of the epidermal barrier function and its interaction with components of the innate and adaptive immune responses in patients with atopic dermatitis (AD) give rise to a number of novel potential treatment options. In particular, the identification of loss-of-function mutations in the barrier protein filaggrin and of a diminished expression of certain antimicrobial peptides in AD skin stimulates new concepts to think beyond the TH 1/TH 2 paradigm. This review will focus on these most recent discoveries and will discuss new and corresponding proof-of-concept trials in patients with AD. It will further speculate on novel ways to restore the homeostasis among the 3 major components in AD skin suspected to be clinically relevant.