Journal of allergy and clinical immunology, 2008-12, Vol.122 (6), p.1074-1081
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Atopic dermatitis: Therapeutic concepts evolving from new pathophysiologic insights
- Ist Teil von
- Journal of allergy and clinical immunology, 2008-12, Vol.122 (6), p.1074-1081
- Ort / Verlag
- New York, NY: Mosby, Inc
- Erscheinungsjahr
- 2008
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Recent insights into the relevance of the epidermal barrier function and its interaction with components of the innate and adaptive immune responses in patients with atopic dermatitis (AD) give rise to a number of novel potential treatment options. In particular, the identification of loss-of-function mutations in the barrier protein filaggrin and of a diminished expression of certain antimicrobial peptides in AD skin stimulates new concepts to think beyond the TH 1/TH 2 paradigm. This review will focus on these most recent discoveries and will discuss new and corresponding proof-of-concept trials in patients with AD. It will further speculate on novel ways to restore the homeostasis among the 3 major components in AD skin suspected to be clinically relevant.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-6749eISSN: 1097-6825DOI: 10.1016/j.jaci.2008.09.042Titel-ID: cdi_proquest_miscellaneous_69897137
- Format
- –
- Schlagworte
- adaptive immune system, Allergy and Immunology, Atopic dermatitis, Biological and medical sciences, Clinical Trials as Topic, Defects, Dermatitis, Dermatitis, Atopic - immunology, Dermatitis, Atopic - pathology, Dermatitis, Atopic - physiopathology, Dermatitis, Atopic - therapy, Dust, Epidermis - immunology, Epidermis - pathology, Epidermis - physiopathology, filaggrin, Fundamental and applied biological sciences. Psychology, Fundamental immunology, Homeostasis - immunology, Humans, Immune system, immunotherapy, innate immune system, Lipids, Medical sciences, Mutation, Pathogenesis, Peptides, proof-of-concept trial, Proteins, Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis, Skin, skin barrier function, T H17 cells, T H2 cells, Th1 Cells - immunology, Th1 Cells - pathology, Th2 Cells - immunology, Th2 Cells - pathology