Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1819-1824
1999
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Details
- Autor(en) / Beteiligte
- Titel
- Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1819-1824
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 1999
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM. On the basis of a systematic SAR analysis of substituted quinolines the powerful antagonist 32 (EC 50 = 0.24 nM) was synthesized.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/S0960-894X(99)00291-7Titel-ID: cdi_proquest_miscellaneous_69896229
- Format
- –
- Schlagworte
- Aminoquinolines - chemical synthesis, Aminoquinolines - pharmacology, Biological and medical sciences, Chloroquine - analogs & derivatives, CpG Islands - immunology, Immunomodulators, Kinetics, Medical sciences, Oligonucleotides - antagonists & inhibitors, Pharmacology. Drug treatments, Structure-Activity Relationship