Journal of Chromatography A, 1999-06, Vol.844 (1), p.171-179
1999
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Details
- Autor(en) / Beteiligte
- Titel
- Optimization and validation of chiral high-performance liquid chromatographic method for analysis of a fibrinogen (gpIIb/IIIa) receptor antagonist
- Ist Teil von
- Journal of Chromatography A, 1999-06, Vol.844 (1), p.171-179
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1999
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- A chiral HPLC separation on an α 1-acid glycoprotein (AGP) column was developed for the separation of roxifiban, a fibrinogen receptor antagonist, from its related chiral impurities. The proposed method was optimized for mobile phase buffer concentration, organic modifier, and temperature using experimental design. The method was then validated for use in release testing of the roxifiban drug substance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9673DOI: 10.1016/S0021-9673(99)00172-7Titel-ID: cdi_proquest_miscellaneous_69886118
- Format
- –
- Schlagworte
- Amidines - analysis, Amidines - chemistry, Analysis, Biological and medical sciences, Chromatography, High Pressure Liquid - methods, Fibrinogen receptor antagonist, Fibrinolytic Agents - analysis, General pharmacology, Isoxazoles - analysis, Isoxazoles - chemistry, Medical sciences, Orosomucoid, Pharmacology. Drug treatments, Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors, Quality Control, Roxifiban, Sensitivity and Specificity, Stereoisomerism