Details

Autor(en) / Beteiligte

• Cairo, Stefano
• Armengol, Carolina
• De Reyniès, Aurélien
• Wei, Yu
• Thomas, Emilie
• Renard, Claire-Angélique
• Goga, Andrei
• Balakrishnan, Asha
• Semeraro, Michaela
• Gresh, Lionel
• Pontoglio, Marco
• Strick-Marchand, Hélène
• Levillayer, Florence
• Nouet, Yann
• Rickman, David
• Gauthier, Frédéric
• Branchereau, Sophie
• Brugières, Laurence
• Laithier, Véronique
• Bouvier, Raymonde
• Boman, Françoise
• Basso, Giuseppe
• Michiels, Jean-François
• Hofman, Paul
• Arbez-Gindre, Francine
• Jouan, Hélène
• Rousselet-Chapeau, Marie-Christine
• Berrebi, Dominique
• Marcellin, Luc
• Plenat, François
• Zachar, Dominique
• Joubert, Madeleine
• Selves, Janick
• Pasquier, Dominique
• Bioulac-Sage, Paulette
• Grotzer, Michael
• Childs, Margaret
• Fabre, Monique
• Buendia, Marie-Annick

Titel

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

Ist Teil von

• Cancer cell, 2008-12, Vol.14 (6), p.471-484

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2008

Quelle

ScienceDirect

Beschreibungen/Notizen

• Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/β-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. β-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chromosomes 8q and 2p and upregulated Myc signaling. Myc-induced hepatoblastoma-like tumors in mice strikingly resembled the human immature subtype, and Myc downregulation in hepatoblastoma cells impaired tumorigenesis in vivo. Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy.