European journal of clinical nutrition, 2008-12, Vol.62 (12), p.1364-1371
2008
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- Autor(en) / Beteiligte
- Titel
- Effects of sucromalt on postprandial responses in human subjects
- Ist Teil von
- European journal of clinical nutrition, 2008-12, Vol.62 (12), p.1364-1371
- Ort / Verlag
- London: Nature Publishing Group UK
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Backgroud/Objective: To compare postprandial responses elicited by sucromalt, a nutritive sweetener produced by treating a blend of sucrose and corn syrup with an enzyme from Leuconostoc mesenteroides, with those after 42% of high-fructose corn syrup (HFCS), and to see if the reduced responses after sucromalt could be accounted for by carbohydrate malabsorption. Subject and Methods: Three experiments were performed in separate groups of normal subjects studied after overnight fasts using double-blind, randomized, cross-over designs. HFCS was used as the control because it contained a similar amount of fructose as sucromalt. Experiment 1 (n=10): plasma glucose and insulin were measured after 50 g sucromalt and 50 g HFCS. Experiment 2 (n=10): metabolic profiles were measured after 80 g HFCS, 80 g sucromalt or 56 g fructose/glucose blend plus 24 g inulin. Experiment 3 (n=20): the glycaemic indices of sucromalt and HFCS were determined. Results: Mean glucose and insulin responses after sucromalt were 66 and 62%, respectively, of those after HFCS (P<0.05). The inulin treatment, used to mimic the effects of carbohydrate malabsorption, elicited higher breath hydrogen (H2), lower glucose and insulin responses, and a significantly earlier rise in serum free fatty acids (FFA) than those of HFCS (all P<0.05). Sucromalt elicited no rise in breath H2, and delayed falls in glucose and insulin, and a delayed rebound of FFA compared to HFCS (all P<0.05). Conclusions: The reduced glucose and insulin responses elicited by sucromalt are not explained by malabsorption and are more likely related to differences in either rate of digestion and absorption or postabsorptive handling by body.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0954-3007eISSN: 1476-5640DOI: 10.1038/sj.ejcn.1602890Titel-ID: cdi_proquest_miscellaneous_69860449
- Format
- –
- Schlagworte
- Absorption, Adult, Area Under Curve, Biological and medical sciences, Blood Glucose - metabolism, Breath Tests, carbohydrate malabsorption, carbohydrate metabolism, Carbohydrates, Clinical Nutrition, Corn, Corn syrup, Cross-Over Studies, Dietary Carbohydrates - pharmacokinetics, digestive physiology, Disaccharides - pharmacokinetics, Double-Blind Method, enzymatic treatment, Epidemiology, Experiments, Fatty acids, Feeding. Feeding behavior, Female, Fructose, Fructose - pharmacokinetics, Fructose metabolism, Fundamental and applied biological sciences. Psychology, Glucose, Glycemic index, high fructose corn syrup, human nutrition, Human subjects, Humans, Insulin, Insulin - blood, insulin secretion, Internal Medicine, Intestinal Absorption - drug effects, Intestinal Absorption - physiology, Inulin, Kinetics, Leuconostoc mesenteroides, Malabsorption, Male, Medical sciences, Medicine, Medicine & Public Health, Metabolic Diseases, Metabolism, Natural sweeteners, Nutrition, nutritive sweeteners, nutritive value, original-article, Postprandial Period, postprandial state, Properties, Public Health, sucromalt, Sucrose, Sucrose - pharmacokinetics, sweeteners, Syrup, Vegetables, Vertebrates: anatomy and physiology, studies on body, several organs or systems, Zea mays