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IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family
Ist Teil von
The Journal of biological chemistry, 1999-07, Vol.274 (27), p.19403-19410
Ort / Verlag
United States: American Society for Biochemistry and Molecular Biology
Erscheinungsjahr
1999
Quelle
MEDLINE
Beschreibungen/Notizen
The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and
has later been implicated in signal transduction of other members of the Toll/IL-1 receptor family. We now report the identification
and characterization of a novel IRAK-like molecule. In contrast to the ubiquitously expressed IRAK and IRAK-2, this new IRAK-like
molecule is found mainly in cells of monomyeloic origin and is, therefore, designated IRAK-M. Although IRAK-M and IRAK-2 exhibit
only a negligible autophosphorylation activity, they can reconstitute the IL-1 response in a 293 mutant cell line lacking
IRAK. In addition, we show for the first time that members of the IRAK family are indispensable elements of lipopolysaccharide
signal transduction. The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members
of the Toll/IL-1 receptor family.