Details

Autor(en) / Beteiligte

• Wesche, H
• Gao, X
• Li, X
• Kirschning, C J
• Stark, G R
• Cao, Z

Titel

IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family

Ist Teil von

• The Journal of biological chemistry, 1999-07, Vol.274 (27), p.19403-19410

Ort / Verlag

United States: American Society for Biochemistry and Molecular Biology

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of other members of the Toll/IL-1 receptor family. We now report the identification and characterization of a novel IRAK-like molecule. In contrast to the ubiquitously expressed IRAK and IRAK-2, this new IRAK-like molecule is found mainly in cells of monomyeloic origin and is, therefore, designated IRAK-M. Although IRAK-M and IRAK-2 exhibit only a negligible autophosphorylation activity, they can reconstitute the IL-1 response in a 293 mutant cell line lacking IRAK. In addition, we show for the first time that members of the IRAK family are indispensable elements of lipopolysaccharide signal transduction. The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family.