Details

Autor(en) / Beteiligte

• Stan, Alexandru C
• Walter, Gerhard F
• Welte, Karl
• Schneider, Berthold
• Bona, Constantin A
• Pietsch, Torsten

Titel

Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression

Ist Teil von

• Journal of neuroimmunology, 1999-02, Vol.94 (1), p.66-73

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

1999

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.