Details

Autor(en) / Beteiligte

• Fukada, S.Y.
• Silva, T.A.
• Saconato, I.F.
• Garlet, G.P.
• Ávila-Campos, M.J.
• Silva, J.S.
• Cunha, F.Q.

Titel

iNOS -derived Nitric Oxide Modulates Infection-stimulated Bone Loss

Ist Teil von

• Journal of dental research, 2008-12, Vol.87 (12), p.1155-1159

Ort / Verlag

United States: SAGE Publications

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) plays an important role in host defense, as well as in inflammation-induced tissue lesions. Here we evaluated the role of NO in bone loss in bacterial infection-induced apical periodontitis by using iNOS-deficient mice (iNOS−/−). The iNOS−/− mice developed greater inflammatory cell recruitment and osteolytic lesions than WT mice. Moreover, tartrate-resistant acid-phosphatase-positive (TRAP+) osteoclasts were significantly more numerous in iNOS−/− mice. Furthermore, the increased bone resorption in iNOS−/− mice also correlated with the increased expression of receptor activator NF-kappaB (RANK), stromal-cell-derived factor-1α (SDF-1α/CXCL12), and reduced expression of osteoprotegerin (OPG). These results show that NO deficiency was associated with an imbalance of bone-resorption-modulating factors, leading to severe infection-stimulated bone loss.