The New England journal of medicine, 1999-06, Vol.340 (24), p.1872-1879
1999
Details
- Autor(en) / Beteiligte
- Titel
- Plasma Normetanephrine and Metanephrine for Detecting Pheochromocytoma in von Hippel–Lindau Disease and Multiple Endocrine Neoplasia Type 2
- Ist Teil von
- The New England journal of medicine, 1999-06, Vol.340 (24), p.1872-1879
- Ort / Verlag
- Boston, MA: Massachusetts Medical Society
- Erscheinungsjahr
- 1999
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Von Hippel–Lindau disease and multiple endocrine neoplasia type 2 (MEN-2) are multisystem neoplastic disorders, inherited in an autosomal dominant fashion, that account for most currently identified familial pheochromocytomas. 1 In patients with von Hippel–Lindau disease, family-specific mutations determine the varied clinical manifestations, which — in addition to pheochromocytomas — include retinal angiomas, cerebellar hemangioblastomas, and renal, pancreatic, and epididymal tumors. In addition to pheochromocytomas, patients with MEN-2 are predisposed to have medullary thyroid carcinoma and hyperparathyroidism in the A subtype and mucosal neuromas in the B subtype. The recommended periodic screening for pheochromocytomas in patients with von Hippel–Lindau disease or MEN-2 . . .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJM199906173402404Titel-ID: cdi_proquest_miscellaneous_69791844
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Biochemistry, Biological and medical sciences, Catecholamines, Complications, Diagnosis, Disease, Endocrinopathies, Epinephrine - blood, Epinephrine - urine, Female, General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes, Humans, Male, Medical research, Medical sciences, Medical screening, Metanephrine - blood, Metanephrine - urine, Middle Aged, Multiple Endocrine Neoplasia Type 2a - complications, Multiple Endocrine Neoplasia Type 2a - metabolism, Neurology, Norepinephrine - blood, Norepinephrine - urine, Normetanephrine - blood, Normetanephrine - urine, Pheochromocytoma, Pheochromocytoma - diagnosis, Pheochromocytoma - etiology, Pheochromocytoma - metabolism, Plasma, Sensitivity and Specificity, Tumors, Tumors of the nervous system. Phacomatoses, Vanilmandelic Acid - urine, Von Hippel-Lindau disease, von Hippel-Lindau Disease - complications, von Hippel-Lindau Disease - metabolism