British journal of haematology, 1999-05, Vol.105 (2), p.431-433
1999
Details
- Autor(en) / Beteiligte
- Titel
- Two case studies of chronic idiopathic neutropenia preceding acute myeloid leukaemia
- Ist Teil von
- British journal of haematology, 1999-05, Vol.105 (2), p.431-433
- Ort / Verlag
- Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd
- Erscheinungsjahr
- 1999
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic idiopathic neutropenia is regarded as a benign disorder without risk of malignant transformation. We present two patients with chronic idiopathic neutropenia who showed disease progression to acute myeloid leukaemia. Sequence analysis of the granulocyte‐colony stimulating factor receptor (G‐CSFR) gene from leukaemic DNA did not reveal any mutations and microsatellite analysis provided no evidence of microsatellite instability or loss of constitutional heterozygosity. These case studies suggest that chronic idiopathic neutropenia may constitute a preleukaemic condition in some patients. Alterations of the G‐CSFR or defective DNA mismatch repair do not appear to be involved in malignant transformation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-1048eISSN: 1365-2141DOI: 10.1111/j.1365-2141.1999.01322.xTitel-ID: cdi_proquest_miscellaneous_69771421
- Format
- –
- Schlagworte
- Acute Disease, acute myeloid leukaemia, Aged, Biological and medical sciences, cancer predisposition, Cell Transformation, Neoplastic, chronic idiopathic neutropenia, Female, granulocyte‐colony stimulating factor receptor, Hematologic and hematopoietic diseases, Hematology, Humans, Leukemia, Myeloid - etiology, Leukemia, Myeloid - genetics, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Male, Medical sciences, microsatellites, Middle Aged, Neutropenia - complications, Neutropenia - genetics, Pedigree, Receptors, Granulocyte Colony-Stimulating Factor - genetics