Details

Autor(en) / Beteiligte

• Chuang, S-S
• Ye, H
• Yang, S-F
• Huang, W-T
• Chen, H-K
• Hsieh, P-P
• Hwang, W-S
• Chang, K-Y
• Lu, C-L
• Du, M-Q

Titel

Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma

Ist Teil von

• Histopathology, 2008-10, Vol.53 (4), p.432-440

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Aims:  To elucidate the clinicopathological features and prognostic factors of primary intestinal diffuse large B‐cell lymphoma (PI‐DLBL). Methods and results:  Archival tissues from 30 tumours were used for tissue microarray construction, immunohistochemistry and interphase fluorescence in situ hybridization for chromosomal translocation. The M:F ratio was 1.7:1, with a median age of 60 years. The ileum and ileocaecum were most frequently involved (40% each). Fourteen (47%) were at stage IE disease, 15 (50%) at stage IIE. Five (17%) tumours were perforated at presentation. The tumours expressed Bcl‐6 (73%), MUM1 (70%), Bcl‐2 (67%) and CD10 (23%). Nine (30%) were classified as germinal centre B‐cell (GCB) phenotype and 21 non‐GCB. Eight of 30 (27%), 7/30 (23%) and 2/29 (7%) cases were positive for rearrangements involving IGH, BCL6, and C‐MYC loci, respectively, whereas all cases were negative for BCL2 and CCND1 translocation. Perforation was a poor prognostic indicator, with a hazard ratio of tumour‐related death at 8.75 (P = 0.001). The differentiation antigens, GCB versus non‐GCB phenotype, or lymphoma‐associated translocations were of no prognostic significance. Conclusions:  We found a higher rate of perforation and lower frequency of GCB phenotype in PI‐DLBL in Taiwan compared with other geographical areas; perforation is a poor prognostic indicator.