Details

Autor(en) / Beteiligte

• Robbers-Visser, Daniëlle
• Helderman, Frank
• Strengers, Jan L.
• van Osch-Gevers, Lennie
• Kapusta, Livia
• Pattynama, Peter M.
• Bogers, Ad J.
• Krams, Rob
• Helbing, Willem A.

Titel

Pulmonary artery size and function after Fontan operation at a young age

Ist Teil von

• Journal of magnetic resonance imaging, 2008-11, Vol.28 (5), p.1101-1107

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Purpose To assess pulmonary artery (PA) size, flow variables, and wall shear stress (WSS) in patients after Fontan operation at a young age. Materials and Methods Flow in the branch PA was obtained with phase contrast velocity‐encoded cardiovascular magnetic resonance imaging in 14 patients before and after low‐dose dobutamine stress (7.5 μg/kg/min) and in 17 healthy controls at rest. Results At rest, stroke index, total flow, average, and peak flow rate were all statistically significantly lower in patients than in controls (P < 0.001). With stress‐testing, all variables increased in patients (P < 0.001), apart from stroke index, which did not change. At rest, branch PA area did not differ between patients and controls. Distensibility was lower in patients than in controls (P < 0.001). With stress‐testing, area and distensibility did not change. At rest, WSS was lower in patients than in controls (P < 0.001). WSS increased with stress‐testing (P < 0.001), but not to the same levels as during resting conditions of the control group. Conclusion PA size is normal long‐term after Fontan operation at a young age. Flow variables, distensibility, and WSS are significantly lower compared to healthy controls, and do not show adequate reactions with stress‐testing, which is suggestive of pulmonary artery endothelial and/or vascular dysfunction. J. Magn. Reson. Imaging 2008;28:1101–1107. © 2008 Wiley‐Liss, Inc.