Details

Autor(en) / Beteiligte

• van der Sar, Sonia A
• Lang, Gerhard
• Mitova, Maya I
• Blunt, John W
• Cole, Anthony L. J
• Cummings, Nicholas
• Ellis, Gill
• Munro, Murray H. G

Titel

Biosynthesis of spiro-Mamakone A, a Structurally Unprecedented Fungal Metabolite

Ist Teil von

• Journal of organic chemistry, 2008-11, Vol.73 (21), p.8635-8638

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Biosynthetic studies on spiro-mamakone A (1), a potently cytotoxic and antimicrobial compound from an endophytic fungus isolated from the New Zealand native tree Knightia excelsa (rewarewa), confirm the polyketide origins of this unique compound belonging to the spirobisnaphthalene class of compounds. The biosynthesis proceeds via an unprecedented symmetric enedione with the two halves of the molecule being formed from two separate pentaketide units connected by oxidative coupling.