Details

Autor(en) / Beteiligte

• Lee, I‐Wen
• Kuan, Long‐Ching
• Lin, Chien‐Hung
• Pan, Hsien‐An
• Hsu, Chao‐Chin
• Tsai, Yung‐Chieh
• Kuo, Pao‐Lin
• Teng, Yen‐Ni

Titel

Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect

Ist Teil von

• Asian journal of andrology, 2008-11, Vol.10 (6), p.896-904

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Aim： To complete comprehensive haplotype analysis of USP26 for both fertile and infertile men. Methods： Two hundred infertile men with severe oligospermia or non-obstructive azoospermia were subjected to sequence analysis for the entire coding sequences of the USP26 gene. Two hundred men with proven fertility were genotyped by primer extension methods. Allele/genotype frequencies, linkage disequilibrium （LD） characteristics and haplotypes of fertile men were compared with infertile men. Results： The allele frequencies of five single nucleotide polymor- phisms （370-37 linsACA, 494T〉C, 576G〉A, ss6202791C〉T, 1737G〉A） were significantly higher in infertile patients than control subjects. The major haplotypes in infertile men were TACCGA （28% of the population）, TGCCGA （15%）, TACCAA （8%）, TGCCAA （6%）, TATCAA （5%） and CATCAA （5%）. The major haplotypes for the control subjects were TACCGA （58% of the population）, CACCGA （7%）, CATCGA （6%） and TGCCGA （5%）. Haplotypes TGCCGA, TATCAA, CATCAA, CATCGC, TACCAA and TGCCAA were over-transmitted in patients with spermato- genic defect, whereas haplotypes TACCGA, CACCGA, and CATCGA were under-transmitted in these patients. Conclusion： Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan, China.