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Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal women
Ist Teil von
Fertility and sterility, 1999-04, Vol.71 (4), p.663-670
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
1999
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Objective: To study the effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity.
Design: Prospective, randomized, controlled study.
Setting: Academic hospital.
Patient(s): Healthy postmenopausal women with an intact uterus.
Intervention(s): For the first 12 months, the hormone replacement therapy group (n = 14) received oral E
2, 1 mg daily, sequentially combined with 5 or 10 mg of dydrogesterone. Thereafter, they received oral E
2, 2 mg daily, sequentially combined with 10 mg of dydrogesterone. The control group (n = 13) received no treatment. Data were collected at baseline and at 3, 12, and 15 months.
Main Outcome Measure(s): Parameters of endothelial function and inflammatory activity.
Result(s): During 12 months of follow-up, we observed decreases of 15% in plasma levels of endothelin-1, of 21% in soluble thrombomodulin, of 14% in von Willebrand factor, and of 12% in clottable fibrinogen in the hormone replacement therapy group compared with the control group. There was a 5% decrease in soluble E-selectin levels. All significant changes were observed by 3 months and sustained after 15 months. Brachial artery flow-mediated vasodilatation and C-reactive protein levels did not change significantly.
Conclusion(s): Long-term combined hormone replacement therapy with E
2 and dydrogesterone in healthy women was associated with sustained improvement in some aspects of endothelial function and in clottable fibrinogen levels.