Neuroscience letters, 1999-03, Vol.262 (2), p.137-139
- Wavrant-DeVrièze, Fabienne
- Rudrasingham, Varuni
- Lambert, Jean-Charles
- Chakraverty, Sumi
- Kehoe, Patrick
- Crook, Richard
- Amouyel, Philippe
- Wu, William
- Holmans, Peter
- Rice, Francis
- Pérez-Tur, Jordi
- Frigard, Bernard
- Morris, John C
- Carty, Stephanie
- Cottel, Dominique
- Tunstall, Nigel
- Lovestone, Simon
- Petersen, Ronald C
- Chartier-Harlin, Marie-Christine
- Goate, Alison
- Owen, Michael J
- Williams, Julie
- Hardy, John
1999
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- Autor(en) / Beteiligte
- Wavrant-DeVrièze, Fabienne
- Rudrasingham, Varuni
- Lambert, Jean-Charles
- Chakraverty, Sumi
- Kehoe, Patrick
- Crook, Richard
- Amouyel, Philippe
- Wu, William
- Holmans, Peter
- Rice, Francis
- Pérez-Tur, Jordi
- Frigard, Bernard
- Morris, John C
- Carty, Stephanie
- Cottel, Dominique
- Tunstall, Nigel
- Lovestone, Simon
- Petersen, Ronald C
- Chartier-Harlin, Marie-Christine
- Goate, Alison
- Owen, Michael J
- Williams, Julie
- Hardy, John
- Titel
- No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease
- Ist Teil von
- Neuroscience letters, 1999-03, Vol.262 (2), p.137-139
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 1999
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3940eISSN: 1872-7972DOI: 10.1016/S0304-3940(99)00035-XTitel-ID: cdi_proquest_miscellaneous_69684698
- Format
- –
- Schlagworte
- Age of Onset, Alleles, alpha-Macroglobulins - genetics, Alzheimer Disease - epidemiology, Alzheimer Disease - genetics, Alzheimer's disease, Apolipoprotein E, Apolipoproteins E - genetics, Biological and medical sciences, Case-Control Studies, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Gene Frequency, Genetic Linkage, Genetics, Genotype, Humans, Lod Score, Medical sciences, Middle Aged, Neurology, Nuclear Family, Polymorphism, Genetic - genetics, Polymorphism, Restriction Fragment Length, α2-macroglobulin