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Primary follicular lymphoma of the testis in childhood
Cancer, 1999-04, Vol.85 (7), p.1626-1635
Finn, Laura S.
Viswanatha, David S.
Belasco, Jean B.
Snyder, Howard
Huebner, David
Sorbara, Lynn
Raffeld, Mark
Jaffe, Elaine S.
Salhany, Kevin E.
1999
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Finn, Laura S.
Viswanatha, David S.
Belasco, Jean B.
Snyder, Howard
Huebner, David
Sorbara, Lynn
Raffeld, Mark
Jaffe, Elaine S.
Salhany, Kevin E.
Titel
Primary follicular lymphoma of the testis in childhood
Ist Teil von
Cancer, 1999-04, Vol.85 (7), p.1626-1635
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
1999
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND Follicular lymphoma in childhood is rare. The authors present four unusual primary follicular lymphomas of the testis in children. METHODS Tumor tissue was evaluated using light microscopy, immunohistochemistry, flow cytometry, and polymerase chain reaction (PCR) for immunoglobulin heavy chain (IgH) and bcl‐2 gene rearrangements. Southern blot and immunohistochemical analyses were used to detect bcl‐6 gene rearrangements and protein expression, respectively. RESULTS Four young boys ranging in age from 3 to 10 years were diagnosed with Stage IE follicular large cell lymphoma (Grade 3). A B‐cell phenotype was documented in all four cases; monoclonality was confirmed in three cases by demonstration of light chain restriction or clonal IgH gene rearrangement. None of the lymphomas expressed Bcl‐2 or p53 protein, and bcl‐2 gene rearrangements were not found in the three lymphomas studied. In contrast, Bcl‐6 protein was expressed by all three lymphomas studied, and a bcl‐6 gene rearrangement was detected in the one case analyzed by Southern blot. All four boys were treated by orchiectomy and combination chemotherapy and are alive with no evidence of disease 18–44 months following their initial diagnoses. CONCLUSIONS Follicular lymphomas may rarely occur as primary testicular tumors in prepubertal boys and, when localized, appear to be associated with a favorable prognosis. In contrast to follicular lymphoma in adults, pediatric follicular lymphomas of the testis are usually of large cell type (Grade 3) and lack bcl‐2 or p53 abnormalities. The identification, in one case, of a bcl‐6 gene rearrangement suggests an alternate molecular pathogenesis for pediatric follicular lymphoma. Cancer 1999;85:1626–35. © 1999 American Cancer Society. Four young children developed primary follicular large cell lymphoma of the testis. The absence of bcl‐2 gene rearrangements and protein expression and the presence of Bcl‐6 protein expression and gene abnormalities suggest a different pathogenesis for childhood and adult follicular lymphoma.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/(SICI)1097-0142(19990401)85:7<1626::AID-CNCR27>3.0.CO;2-0
Titel-ID: cdi_proquest_miscellaneous_69681488
Format
–
Schlagworte
bcl‐2
,
bcl‐6
,
Biological and medical sciences
,
Child
,
Child, Preschool
,
follicular lymphoma
,
Gene Rearrangement
,
Hematologic and hematopoietic diseases
,
Humans
,
Immunophenotyping
,
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
,
Lymphoma, B-Cell - genetics
,
Lymphoma, Follicular - genetics
,
Lymphoma, Follicular - pathology
,
Male
,
Medical sciences
,
p53
,
pediatric lymphoma
,
Proto-Oncogene Proteins c-bcl-2 - analysis
,
testicular lymphoma
,
testicular neoplasm
,
Testicular Neoplasms - genetics
,
Testicular Neoplasms - pathology
,
Tumor Suppressor Protein p53 - analysis
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