Details

Autor(en) / Beteiligte

• Coote, Michael A
• Ruddle, Jonathan B
• Qin, Queena
• Crowston, Jonathan G

Titel

Vascular Changes After Intra-bleb Injection of Bevacizumab

Ist Teil von

• Journal of glaucoma, 2008-10, Vol.17 (7), p.517-518

Ort / Verlag

United States: Lippincott Williams & Wilkins, Inc

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• PURPOSETo illustrate changes in bleb vascularity after subconjunctival bevacizumab injection. METHODSLongitudinal changes in bleb vascularity were followed over 6 months pre and postbevacizumab injection. RESULTSBleb vascularity associated with increased scarring activity was observed 10 days postcataract surgery in an eye that had undergone trabeculectomy 3 months previously. A single subconjunctival avastin injection led to a dramatic reduction in bleb vascularity for 6 weeks. With continued steroids, a diffuse, healthy, well functioning bleb with minimal scar tissue was present at 6 months. CONCLUSIONSSubconjunctival injection of bevacizumab reduced bleb vascularity and may provide an adjunct to current antifibrosis therapy. Further studies to establish the effect of bevacizumab on postoperative scaring are warranted.