Bioorganic & medicinal chemistry letters, 1999-02, Vol.9 (4), p.585-588
1999
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and SAR of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 1999-02, Vol.9 (4), p.585-588
- Ort / Verlag
- Oxford: Elsevier
- Erscheinungsjahr
- 1999
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- 7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D4 ligands. Highest affinity and selectivity for the D4 receptor resided in the 3-aminomethyl-7-azaindole series.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/S0960-894X(99)00025-6Titel-ID: cdi_proquest_miscellaneous_69654214
- Format
- –
- Schlagworte
- Aza Compounds - chemistry, Biological and medical sciences, Catecholaminergic system, Humans, Indoles - chemical synthesis, Indoles - chemistry, Indoles - metabolism, Ligands, Medical sciences, Molecular Structure, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Pharmacology. Drug treatments, Protein Binding, Receptors, Dopamine D2 - metabolism, Receptors, Dopamine D4, Structure-Activity Relationship