Details

Autor(en) / Beteiligte

• Colin, Jean‐François
• Cazals‐Hatem, Dominique
• Loriot, Marie Anne
• Martinot‐Peignoux, Michèle
• Pham, Bach Nga
• Auperin, Anne
• Degott, Claude
• Benhamou, Jean‐Pierre
• Erlinger, Serge
• Valla, Dominique
• Marcellin, Patrick

Titel

Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men

Ist Teil von

• Hepatology (Baltimore, Md.), 1999-04, Vol.29 (4), p.1306-1310

Ort / Verlag

Philadelphia, PA: W.B. Saunders

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti‐HIV positive) homosexual non–drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) replication was assessed with serum HBV DNA level and with immunoperoxidase staining of hepatitis B core (HBc) antigen on liver specimens; and the severity of liver lesions was assessed with an histology activity index. Anti‐HIV–positive and anti‐HIV–negative patients were not different for serum aspartate transaminase activity, bilirubin, prothrombin, and histology activity index. Anti‐HIV–positive patients had lower serum alanine transaminase activity levels (P = .0001), lower serum albumin levels (P = .0009), and higher serum HBV DNA levels (P = .01). There was a higher prevalence of cirrhosis in anti‐HIV–positive patients (P = .04). In homosexual men with chronic hepatitis B, HIV infection is associated with a higher level of HBV replication and a higher risk for cirrhosis without increased liver necrotico‐inflammatory process.