Details

Autor(en) / Beteiligte

• Hori, Y.
• Tsubaki, M.
• Katou, A.
• Ono, Y.
• Yonezawa, T.
• Li, X.
• Higuchi, S.-I.

Titel

Evaluation of NT-Pro BNP and CT-ANP as Markers of Concentric Hypertrophy in Dogs with a Model of Compensated Aortic Stenosis

Ist Teil von

• Journal of veterinary internal medicine, 2008-09, Vol.22 (5), p.1118-1123

Ort / Verlag

Malden, USA: Blackwell Publishing Inc

Erscheinungsjahr

2008

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Background: Serum C‐terminal atrial natriuretic peptide (CT‐ANP) and N‐terminal pro B‐type natriuretic peptide (NT‐pro BNP) concentrations have not been measured serially in dogs with chronic pressure overload of the heart. Hypothesis: We investigated whether serial evaluation of CT‐ANP and NT‐pro BNP concentrations is a useful guide to the risk of cardiac remodeling in dogs with a model of aortic stenosis. Animals: Six male Beagles. Methods: After anesthesia, the aorta was constricted with a polyester band and mean left ventricular systolic pressure (LVPs) was 50 mmHg above baseline. Echocardiographic and intracardiac catheter examinations and blood sampling were performed before surgery and 3 and 6 months after surgery. Results: LVP and left ventricular end‐diastolic pressure (LVEDP) were significantly higher at 6 months. Compared with baseline, end‐diastolic intraventricular septum thickness (IVSd), left ventricular posterior wall thickness (LVPWd), and relative wall thickness (RWT) were significantly increased 3 and 6 months after aortic constriction. Serum CT‐ANP concentrations were increased significantly at 3 months and serum NT‐pro BNP concentrations were significantly higher 3 and 6 months after aortic constriction. Serum NT‐pro BNP concentration was significantly correlated with LVEDP and IVSd whereas serum CT‐ANP concentration was not correlated with any measurement. Stepwise regression analysis showed that LVEDP, IVSd, and RWT could predict serum NT‐pro BNP. Conclusions and Clinical Importance: This study indicated the differential regulation of NT‐pro BNP and CT‐ANP concentrations during pressure overload. NT‐pro BNP assay may be used as an additional screening method to stratify early‐stage ventricular remodeling because of aortic constriction.