Cancer genetics and cytogenetics, 1999-03, Vol.109 (2), p.123-125
1999
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- MYC Amplification in Two Further Cases of Acute Myeloid Leukemia with Trisomy 4 and Double Minute Chromosomes
- Ist Teil von
- Cancer genetics and cytogenetics, 1999-03, Vol.109 (2), p.123-125
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1999
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- We report two cases of trisomy 4 with double minute chromosomes (dmin): one in a woman with acute myeloid leukemia (AML), French-American-British subtype M2, the other in a man with chronic myelomonocytic leukemia. In the former case, many cells without trisomy 4 but with dmin were present, a finding not observed in previously reported cases. In both cases, fluorescence in situ hybridization studies demonstrated the double minutes to be MYC amplicons. Ten cases of AML with trisomy 4 and dmin have now been described; in the five cases investigated, the dmin have been shown to be amplified MYC gene sequences.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-4608eISSN: 1873-4456DOI: 10.1016/S0165-4608(98)00160-5Titel-ID: cdi_proquest_miscellaneous_69638403
- Format
- –
- Schlagworte
- Acute Disease, Aged, Biological and medical sciences, Chromosome Aberrations, Chromosomes, Human, Pair 4, Female, Gene Amplification, Genes, myc, Hematologic and hematopoietic diseases, Humans, In Situ Hybridization, Fluorescence, Leukemia, Myeloid - genetics, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Male, Medical sciences, Trisomy