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MYC Amplification in Two Further Cases of Acute Myeloid Leukemia with Trisomy 4 and Double Minute Chromosomes
Ist Teil von
Cancer genetics and cytogenetics, 1999-03, Vol.109 (2), p.123-125
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
1999
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
We report two cases of trisomy 4 with double minute chromosomes (dmin): one in a woman with acute myeloid leukemia (AML), French-American-British subtype M2, the other in a man with chronic myelomonocytic leukemia. In the former case, many cells without trisomy 4 but with dmin were present, a finding not observed in previously reported cases. In both cases, fluorescence in situ hybridization studies demonstrated the double minutes to be
MYC amplicons. Ten cases of AML with trisomy 4 and dmin have now been described; in the five cases investigated, the dmin have been shown to be amplified
MYC gene sequences.