Details

Autor(en) / Beteiligte

• Mori, S.-I
• Nagashima, M
• Sasaki, Y
• Mori, K
• Tabei, Y
• Yoshida, Y
• Yamazaki, K
• Hirata, I
• Sekine, H
• Ito, T
• Suzuki, S

Titel

novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997–1998 season in Tokyo

Ist Teil von

• Archives of virology, 1999, Vol.144 (1), p.147-155

Ort / Verlag

Wien: Springer-Verlag

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• We analyzed the hemagglutinin (HA) genes of influenza A viruses consisting of 6 strains isolated from cerebrospinal fluids of patients with encephalopathy and 3 isolates from throat washes of patients without central nervous system symptoms during the 1997–1998 season in Tokyo. Aligned 9 amino acid sequences showed 7 common substitutions compared with A/Wuhan/359/95 (vaccine strain used in the season in Japan), which were allocated to three different antigenic sites on the H3 HA molecule. It is noted that a novel substitution at the receptor-binding site (Tyr-137 to Phe) was found exclusively in the isolates from the patients with encephalopathy.