Details

Autor(en) / Beteiligte

• Steele, JC
• Bruce, AJ
• Drage, LA
• Rogers III, RS

Titel

α-Lipoic acid treatment of 31 patients with sore, burning mouth

Ist Teil von

• Oral diseases, 2008-09, Vol.14 (6), p.529-532

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2008

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Objective:  To review a series of patients with sore, burning mouth treated with α‐lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. Design:  Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients was a prescription/recommendation for α‐lipoic acid. Of these patients, 35 were available for follow‐up. Setting:  Tertiary care academic medical center. Subjects:  Ambulatory patients given prescription /recommendation for α‐lipoic acid 600 mg per day, in divided doses. Main Outcome Measure:  Reported improvement in symptoms documented in medical records and at follow‐up (visits or telephone interviews). Results:  Thirty‐one of the 35 patients (66% of all 47) actually took α‐lipoic acid as recommended. No patient reported a complete alleviation of symptoms. Six (19%) of these 31 patients felt mostly better, five (16%) felt somewhat better, and 14 (45%) reported no difference. Two patients (7%) reported a worsening of symptoms and four (13%) did not know whether there had been improvement. Conclusion:  Eleven of 31 patients (35%) reported benefit from taking α‐lipoic acid. Because we examined only a small number of patients and relied on a subjective outcome assessment, further larger studies using a prospective, randomized, controlled, and double‐blind structure are warranted.