Nature genetics, 2008-10, Vol.40 (10), p.1156-1159
2008
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- Autor(en) / Beteiligte
- Titel
- Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
- Ist Teil von
- Nature genetics, 2008-10, Vol.40 (10), p.1156-1159
- Ort / Verlag
- New York: Nature Publishing Group US
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−4 − 1 × 10−5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10−5, P = 4 × 10−4 and P = 4 × 10−4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.218Titel-ID: cdi_proquest_miscellaneous_69598382
- Format
- –
- Schlagworte
- Agriculture, Animal Genetics and Genomics, Arthritis, Rheumatoid - genetics, Arthritis, Rheumatoid - pathology, Biomedical and Life Sciences, Biomedicine, brief-communication, Cancer Research, Case-Control Studies, Chromosome Mapping, Chromosomes, Chromosomes, Human, Pair 10 - genetics, Chromosomes, Human, Pair 12 - genetics, Chromosomes, Human, Pair 22 - genetics, Data analysis, Diabetes, Disease susceptibility, Gene Function, Genetic aspects, Genetic Linkage, Genetic Predisposition to Disease - genetics, Human Genetics, Humans, Kinases, Polymorphism, Single Nucleotide - genetics, Rheumatoid arthritis, Risk factors, Sample size, Single nucleotide polymorphisms, Validation studies