FEBS letters, 1999-02, Vol.444 (2), p.250-254
1999
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- Autor(en) / Beteiligte
- Titel
- Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
- Ist Teil von
- FEBS letters, 1999-02, Vol.444 (2), p.250-254
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 1999
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity. UCP3 mRNA expression increased strongly during the hypothyroid-hyperthyroid transition. The rank order of mitochondrial State 3 and State 4 respiration rates was hypothyroid<euthyroid<hyperthyroid. The State 4 increase may have been due to the increased UCP3 expression, as the proton leak kinetic was stimulated in the hypothyroid-hyperthyroid transition and a good correlation exists between the State 4 and UCP3 mRNA level. As a significant proportion of an organism's resting oxygen consumption is dedicated to opposing the proton leak, skeletal muscle mitochondrial UCP3 may mediate part of T3's effect on energy metabolism.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/S0014-5793(99)00061-7Titel-ID: cdi_proquest_miscellaneous_69594092
- Format
- –
- Schlagworte
- Animals, Carrier Proteins - genetics, Energy Metabolism - drug effects, Gene Expression Regulation - genetics, Hyperthyroidism - metabolism, Hypothyroidism - metabolism, Ion Channels, IOP, iopanoic acid, Kinetics, Male, Membrane potential, Mitochondria, Muscle - metabolism, Mitochondrial Proteins, Mitochondrion, Muscle, Skeletal - metabolism, Oxygen Consumption, Protons, PTU, 6-n-propylthiouracil, Rats, Rats, Wistar, RCR, respiratory control ratio, RNA, Messenger - metabolism, Skeletal muscle, State 3, respiratory state in which ATP synthesis is at maximal rate, State 4, respiratory state in which there is no ATP synthesis, T3, triiodothyronine, Thyroid hormone, Triiodothyronine - pharmacology, UCP1, uncoupling protein-1, UCP2, uncoupling protein-2, UCP3, uncoupling protein-3, Uncoupling protein, Uncoupling Protein 3, ΔΨ, mitochondrial transmembrane electric potential difference