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Visible and near-infrared spectral changes in plasma of psychiatric patients
Ist Teil von
International journal of molecular medicine, 2008-10, Vol.22 (4), p.513-519
Ort / Verlag
Greece: D.A. Spandidos
Erscheinungsjahr
2008
Quelle
MEDLINE
Beschreibungen/Notizen
In the present study, the possible difference in visible and near-infrared
(Vis-NIR) spectra of plasma in psychiatric patients compared to healthy control
subjects was investigated. Mean Vis-NIR spectra of 60 psychiatric patients showed
several specific peaks in the 630- to 930-nm region. Principal component analysis
(PCA) and soft independent modeling of class analogy (SIMCA) were applied to manifest
the spectral characteristics of each group. The PCA and SIMCA models demonstrated
successful discrimination of the two groups using a score plot of the third versus
fourth principal component and a Coomans plot, respectively. The PCA loadings
were generally consistent with the discriminating power of the SIMCA model, indicating
a specific pattern of Vis-NIR spectra in the plasma of psychiatric patients. The
specific pattern possibly indicates altered superoxide, amine, and primary and
secondary amides in plasma and may provide a possible indicator for the diagnosis
of heterogeneous psychiatric disorders. This is the first step toward a clinical
tool which has the potential to be applied in the diagnosis of psychiatric disease.
Yet, there remain obstacles to its practical usage.