Details

Autor(en) / Beteiligte

• Mori, Seiichi
• Sugawara, Seiichi
• Kikuchi, Takayuki
• Tanji, Masahiro
• Narumi, Osamu
• Stoykova, Anastassia
• Nishikawa, Shin-Ichi
• Yokota, Yoshifumi

Titel

The leukemic oncogene tal-2 is expressed in the developing mouse brain

Ist Teil von

• Brain research. Molecular brain research., 1999-02, Vol.64 (2), p.199-210

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• tal-1 (T-cell acute leukemia-1; also known as SCL) and tal-2 genes belong to a family of basic helix–loop–helix transcription factors and were originally isolated from the breakpoints of chromosomal translocations in human T-cell leukemia cell lines. tal-1 is expressed not only in hematopoietic cells but also in several endothelial structures and the central nervous system during development. On the other hand, the detailed function and the sites of expression of tal-2 have remained obscure. We cloned the tal-2 cDNA from a mouse embryonic cDNA library and examined its expression pattern in the mouse, comparing with that of tal-1. In situ analyses revealed that tal-2 transcripts are detected at embryonic day 12.5 in the following regions; 1) the diencephalon—the zona limitans intrathalamica and the pretectum, 2) the mesencephalon—the tectum, and the anterior and posterior tegmentum, 3) the metencephalon—the isthmus and the anterior pons. In the diencephalon and the mesencephalon, the expression sites of tal-2 gene were similar to those of tal-1, and its expression was stronger than that of tal-1. In the metencephalon, tal-2 expression was observed in the anterior pons, whereas tal-1 transcripts were detected in the entire pons, and showed stronger expression than tal-2. The tal-2 messages were barely detectable in the brain at birth. These results suggest that tal-1 and tal-2 are involved in the development of specific areas of the central nervous system.